2.5-Dimethoxytetrahydrofuran

English name

2,5-Dimethoxytetrahydrofuran

English synonyms

2,5-Dimethoxytetrahydrofuran,c&t;tetrahydro-2,5-dimethoxy-fura;DMTHF;DIMETHOXYTETRAHYDROFURAN;FURAN,TETRAHYDRO-2,5-DIMETHOChemicalbookXY;2,5-DIMETHOXYTETRAHYDROFURAN;2,5-Dimethoxytetrahydrofuran,mixtureofcisandtrans;2,5-DIMETHOXY-TETRAHYDROFURAN(CIS+TRANS)

CAS number

696-59-3

Molecular formula

C6H12O3

Molecular weight

132.16

EINECS

211-797-1

Related Categories

Furans;Intermediates;Heterocyclic Compounds;Furans;Heterocyclic Building Blocks;Pharmaceutical Raw Materials;General Reagents;Food Additives;Chemical Raw Materials;Other Raw Materials;Oxygencyclic Compounds;Aromatic Hydrocarbons (substituted) & Derivatives;Furan & Benzofuran;Furans;Building Blocks;Chemical Book Heterocyclic Building Blocks;Pharmaceutical;Building Blocks;C4toC7;Chemical Synthesis;Heterocyclic Building Blocks;Organic Chemical Raw Materials;Chemical Solvents;Impurity Reference Standards;Flavors and Fragrances;Fine Chemical Raw Materials;Organic Intermediates;Medical Raw Materials;bc0001

Mol file

696-59-3.mol

Melting point

-45 °C

Boiling point

145-147 °C(lit.)

Density

1.023 g/mL at 20 °C(lit.)

Vapor Pressure

5 hPa (20 °C)

Refractive Index

n20/D 1.418

Flash Point

95 °F

Storage Conditions

Store below +30°C.

Solubility

300 g/L

Form

Liquid

Color

Transparent, colorless to light yellow

pH

5 (300g/l, H2O, 20℃)

Explosive Limit

2.0-12.3%(V)

Water Solubility

350 g/L (20 ºC)

Sensitivity

Air & Light Sensitive

BRN

104261

LogP

0.34 at 20℃

CAS Database

696-59-3(CAS DataBase Reference)

NIST Chemical Substance Information

Furan, tetrahydro-2,5-dimethoxy-(696-59-3)

EPA Chemical Substance Information

Furan, tetrahydro-2,5-dimethoxy- (696-59-3)

Uses

2,5-Dimethoxytetrahydrofuran is a raw material for the synthesis of tropinone. During the production of tropinone, succinaldehyde, obtained by hydrolysis of 2,5-dimethoxytetrahydrofuran, is one of the raw materials for the synthesis of tropinone.

Chemical Properties

It is a colorless liquid. Boiling point: 145-147°C, 52-54°C (2.93 kPa), relative density: 1.023 (20/4°C), refractive index: 1.4182-1.4184, flash point: 35°C. It is miscible with water, ethanol, and ether. It decomposes readily upon heating.

Uses

THF is commonly known as a "universal solvent" due to its low boiling point, good fluidity, strong solubility for many chemicals, and excellent diffusion properties on and within resin surfaces. It is widely used in the plastics, rubber, coatings, adhesives, inks, textiles, and pharmaceutical industries.

Uses

t is an intermediate for the anticholinergic drug atropine sulfate. It is also used as a photographic film hardener. THF is commonly known as a "universal solvent" due to its low boiling point, good fluidity, strong solubility for many chemicals, and excellent diffusion properties on and within resin surfaces. It is widely used in industries such as plastics, rubber, coatings, adhesives, inks, textiles, and pharmaceuticals.

Production Methods

It is obtained by catalytic hydrogenation of 2,5-dimethoxydihydrofuran ([332-77-4]). It can also be prepared by etherifying furan with methanol and catalytic hydrogenation at near-normal pressure, but the yield is lower.

Dangerous Goods Symbol

Xi,Xn

Hazard Classification Code

10-36/37/38-36-20/21

Safety Instructions

26-36-36/37/39-16

Hazardous Goods Transport Code

UN 1993 3/PG 3

WGK Germany

1

Autoignition Temperature

>205 °C

TSCA

Yes

Hazard Class

3

Packaging Group

III

Customs Code

29321900

Toxicity

LD50 orally in Rabbit: 2040 mg/kg

Upstream raw materials

Sodium hydroxide, methanol, ethyl ether, tetrahydrofuran, toluene, potassium carbonate, sodium carbonate, Government regulation, anhydrous magnesium sulfate, benzene, hydrogen, carbon dioxide, nickel, furan, potassium acetate, aluminum-nickel alloy, 2,5-dimethoxy-2,5-dihydrofuran, potassium carbonate-13C

Downstream products

8-(1-methylethyl)-8-azabicyclo[3.2.1]octyl α-formylphenylacetate 8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl α-(hydroxymethyl)phenylacetate 2,3-naphthyl diacetal 3-(1H-pyrrol-1-yl)thiophene-2-carboxylic acid