N,N-Bis(2-chloroethyl)carbamoyl chloride

English synonyms

bis(2-chloroethyl)-carbamicchlorid;bis(2-chloroethyl)-carbamoylchlorid;
bis(2-chloroethyl)carbamoylchloride;bischloroethylcarbamoChemicalbookylchloride;
tl460;N,N-BIS(2-CHLOROETHYL)CARBAMOYLCHLORIDE;bis-(2-Chloroethyl)carbamicchloride;
Bis-(2-chloroethyl)carbamoylhydrochloride

CAS number

2998-56-3

Molecular formula

C5H8Cl3NO

Molecular weight

204.48

EINECS number

221-075-8

Melting point

101-103℃

Boiling point

125℃ 3mm

Density

1,4 g/cm³

Refractive index

1.5060-1.5100

Storage conditions

Inert atmosphere,Room Temperature

Acidity coefficient (pKa)

-2.30±0.70(Predicted)

Form

Transparent liquid

Color

Colorless to light yellow

Chemical Properties

Colorless transparent liquid. Boiling point 114-128℃ /400-533Pa.

Uses

Intermediate of antitumor drug estradiol nitrogen mustard.

Production Method

Prepared by reacting bis(2-chloroethyl)amine, i.e. nitrogen mustard, with phosgene.

Hazardous materials symbol

T

Hazard category code

34-43-25

Safety instructions

26-36/37/39-45

Hazardous materials transport number

3265

RTECS number

FD2200000

Customs code

2929.90.5090

Hazard level

8

Packaging category

Ⅱ

Toxicity

mouse,LC,inhalation,>1540mg/m3/10(1540mg/m3),National Defense Research Committee,
Office of Scie ntific Research and Development,Progress Report.Vol.NDCrc-132,Pg.Nov,1942.

Upstream raw materials

Nitrogen mustard, bis(2-chloroethyl)amine

Downstream products

Estramustine