1-(4-Methoxyphenyl)-2-Benzylaminopropane

English synonyms

P-METHOXYPHENYL-2-BENZYLAMINOPROPANE;N-Benzyl-4-methoxy-alpha-methylphenethylamine;
1-(4-METHOXYPHENYL)-2-(BENZYLAMINO)PROPANE;
4-Methoxy-α-methyl-N-(phenylmethyl)benzeneethanamChemicalbookine;
N-Benzyl-N-(4-methoxy-α-methylphenethyl)amine;1-(3-aMino-2-benzylpropyl)-4-Methoxybenzene;
N-benzyl-1-(4-Methoxyphenyl)propan-2-aMine;N-BENZYL-1-(4-METHOXYPHENYL)PROPANAMINE

CAS number

43229-65-8

Molecular formula

C17H21NO

Molecular weight

255.35

EINECS number

256-155-1

Boiling point

377.8±22.0℃(Predicted)

Density

1.024±0.06 g/cm3(Predicted)

Storage conditions

Keep in dark place,Inert atmosphere,Room temperature

Solubility

Miscible with methanol and dichloromethane. Miscible with water

Acidity coefficient (pKa)

9.54±0.19(Predicted)

Form

Oily

Color

Light yellow to yellow liquid

InChl

InChl=1S/C17H21NO/c1-14(18-13-16-6-4-3-5-7-16)12-15-8-10-17

(19-2)11-9-15/h3-11,

14,18H,12-13H2,1- 2H3

InChlKey

CVGPWMGXKOKNFD-UHFFFAOYSA-N

SMILES

C(C1=CC=C(OC)C=C1)C(NCC1=CC=CC=C1)C

LogP

4.8

Applications

1-(4-methoxyphenyl)-2-benzylaminopropane can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory
research and development processes and pharmaceutical chemical production processes.

Production methods

General method: 1-(4-methoxyphenyl)propan-2-one (8.22 g, 50.0 mmol) 

and benzylamine (5.35 g, 50.0 mmol) were dissolved in methanol,

and 5% Pt/C catalyst (0.83 g) was added. The reaction mixture was stirred at 60°C and hydrogenated for 24 hours. 

After the reaction was completed,

the catalyst was removed by filtration,and the solvent was removed by rotary evaporation to obtain the intermediate

N-benzyl-1-(4-methoxyphenyl)propan-2-amine with a yield of 95%.

The product was characterized by 1HNMR (400MHz, CDCl3): δ7.25

Upstream raw materials

p-Methoxyphenylacetone, benzylamine, carbon, platinum, methanol