2,4-Dichloropyrimidine

English synonyms

2,4-DICHLOROPYRIMIDINE;2,6-DICHLOROPYRIMIDINE;2-4-DICHLOROPYRIMIDINECRYSTALLINE;
AKOS91058;2,Chemicalbook4-dichloro-pyrimidin;2,4-Dichlorpyrimidin;Pyrimidine,
2,4-dichloro-;2,4-DichloropyrimidinePazopanib

CAS number

3934-20-1

Molecular formula

C4H2Cl2N2

Molecular weight

148.98

EINECS number

223-508-6

Melting point

57-61℃(lit.)

Boiling point

101℃/23 mmHg(lit.)

Density

1.6445(rough estimate)

Refractive index

1.6300(estimate)

Flash point

101℃/23mm

Storage conditions

Keep in dark place,Sealed in dry,Room Temperature

Solubility

Soluble in chloroform (a little), ethyl acetate (a little), methanol (a little)

Acidity coefficient (pKa)

-2.84±0.20 (Predicted)

Form

Powder, crystal or block

Color

White to yellow to beige or light gray

Water solubility

Soluble in water (partly), methanol, chloroform, and eth

Sensitivity

Moisture Sensitive

BRN

110911

InChlKey

BTTNYQZNBZNDOR-UHFFFAOYSA-N

CAS database

3934-20-1(CAS DataBase Reference)

NIST chemical information

Pyrimidine,2,4-dichloro-(3934-20-1)

EPA chemical information

Pyrimidine,2,4-dichloro-(3934-20-1)

Chemical properties

Melting point 58-61℃, boiling point 101℃ (3.07kPa).

Uses

Used in the production of drug arabinoside hydrochloride.

Uses

Building blocks for drug chemical synthesis; building blocks for Suzuki coupling, alkylation and other reactions

Production method

Originated from chlorination of uracil. Add uracil, phosphorus oxychloride and dimethylbenzene to the reaction pot,
heat to 130℃, reflux for about 45min, cool slightly, and place in crushed ice to precipitate a purple solid.
Filter while hot and undissolved,wash with ice water, and vacuum dry to obtain a purple crude product.
Decolorize with petroleum ether(boiling range 60-90℃) and recrystallize to obtain 2,4-dichloropyrimidine.

Hazardous goods symbol

Xi

Hazard category code

36/37/38

Safety instructions

26-36-28A

Hazardous goods transport number

1759

WGK Germany

3

TSCA

Yes

Hazard level

8

Packaging category

Ⅲ

Customs code

29335990

Upstream raw materials

Phosphorus oxychloride, uracil, dimethylbenzene

Downstream products

Chlorsulfuron-ethyl, 4(3H)-pyrimidinone, (E)-5-(2-carbonylethylene)-2,4-dimethoxypyrimidine,
4-amino-2-chloropyrimidine, 2,4-dimethoxy-5-iodopyrimidine, 2-chloro-4-hydrazinopyrimidine, N4-methylcytosine,
4-benzyloxy-2-chloropyrimidine, 5-FORMYL-2,4-DIMETHOXYPYRIMIDINE, 2-chloro-4-bromopyrimidine, 2,4-dimethoxypyrimidine,
2,4-diethoxypyrimidine,4-(N,N-dimethylamino)-2-chloropyrimidine, 2-chloro-4-methoxypyrimidine,
2,4-difluoropyrimidine, 4-(3-pyridyl)-2-chloropyrimidine, 5-((2-chloropyrimidin-4-yl)amino)-2-methylphenol