N,O-Bis(trimethylsilyl)acetamide

Category：N,O-Bis(trimethylsilyl)acetamide
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Release time：2023-06-29 10:48:11

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Product description

Product Name	N,O-Bis(trimethylsilyl)acetamide
CAS No.	10416-59-8
Synonyms	dynasylanbsa;Co-FormulaCFS-598; trimethylsilylN-trimethylsilylethanimidate; BIS(TRIMETHYLSILYL)ACETAMIDE; Acetimidicacid,N-(triChemicalbookmethylsilyl)-, trimethylsilylester;bis(trimethylsllyl)acetamide; CB2500;Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester
Molecular formula	C8H21NOSi2
Molecular weight	203.43203.43
EINECS	233-892-7

N,O-Bistrimethylsilylacetamide Chemical Properties
Melting point	24 °C
Boiling Point	71-73 °C35 mm Hg(lit.)
Density	0.832 g/mL at 20 °C(lit.)
Vapor Pressure	10 hPa (50 °C)
Refractive Index	n20/D 1.417(lit.)
Flash point	53 °F
Storage conditions	Store below +30°C.
Solubility	Store below +30°C.
form	Crystalline powder, crystals or lumps
Acidity coefficient (pKa)	5.82±0.50(Predicted)
Proportion	0.832
Color	Light yellow or beige to brown
Hydrolysis sensitivity	7: reacts slowly with moisture/water
Sensitivity	Moisture Sensitive
BRN	1306669

N,O-Bistrimethylsilylacetamide Usage and Synthesis

Product advantages

N,O-Bistrimethylsilylacetamide is a mild neutral silylating agent, which not only has high reaction activity and good selectivity, but also has the advantages of high reaction yield and simple post-processing.

Chemical properties

Colorless or light yellow transparent liquid or solid. Boiling point 71-73℃/35mm.

Uses

Neutral silanization protective agent, BSA product is an important pharmaceutical intermediate, mainly used in the production of synthetic cephalosporin antibiotics.

Uses

It is a protective agent for the preparation of cephalosporin drugs

Uses

N,O-Bistrimethylsilylacetamide can be used as a pharmaceutical intermediate, neutral silanization protective agent, mainly used in the synthesis of cephalosporin antibiotics.

Safety Information
Dangerous goods signs	C,Xn,F
Hazard Category Code	10-14-22-34-40-20/21/22-11
Safety Instructions	26-36/37/39-45-7/8-43A-36-30-23-16-7/9
Dangerous Goods Transport Number	UN 2920 8/PG 2
WGK Germany	3
RTECS	AK3000000
F	45951
TSCA	Yes
Hazard Level	8
Packaging category	II
Customs Code	29310095
Toxicity	LD50 orally in Rabbit: 1580 mg/kg

N,O-Bis(trimethylsilyl)acetamide Upstream and Downstream Product Information

Upstream raw materials

Toluene, trimethylsilyl chloride, acetamide, triethylamine hydrochloride

Downstream products

N-methyl-N-(trimethylsilyl) trifluoroacetamide, N-(trimethylsilyl)-2-(trimethylsilyloxy)-4-pyrimidinamine,
2-methyl-1-(trimethylsilyloxy)-1-propylene, 1-cyclohexenyloxytrimethylsilane, 1-(trimethylsilyloxy)cyclopentene

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N,O-Bis(trimethylsilyl)acetamide

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